Antimicrobial resistance and associated gene mutations of Neisseria gonorrhoeae

  • Thu Pham Hien Anh, Chuong Nguyen Hoang, Van Pham Thi Thanh, Hai Tang Tuan
Từ khóa: Neisseria gonorrhoeae; sexually transmitted infections; antimicrobial resistance; mutation.

Tóm tắt

   Neisseria gonorrhoeae is the causative agent of gonorrhea, a globally prevalent sexually transmitted infection, and was classified by the World Health Organization (WHO) in 2024 as a high-priority bacterial pathogen. The current first-line treatment includes third-generation broad-spectrum cephalosporins (ceftriaxone or cefixime) as monotherapy and/or combined with azithromycin. The increasing resistance to these first-line antibiotics has led experts to include N. gonorrhoeae in this priority list.

N. gonorrhoeae has developed resistance to multiple antibiotics, including penicillins, cephalosporins, azithromycin, fluoroquinolones, and tetracyclines. The emergence and spread of multidrug-resistant strains, which show reduced susceptibility to broad-spectrum cephalosporins and azithromycin, pose a significant global health threat. Resistance mechanisms in N. gonorrhoeae are diverse, and studies have shown that specific mutations influence resistance to cephalosporins and macrolides in key genes. Timely detection of resistant strains and their associated resistance mechanisms is crucial for improving treatment strategies and monitoring the antimicrobial susceptibility profile of Neisseria gonorrhoeae.

DOI: 10.59715/pntjmp.4.2.3

điểm /   đánh giá
Phát hành ngày
2025-04-20
In ra
Tập. 4 Số. 2 (2025)
Chuyên mục
Tổng quan (Review)