A review of molecular mechanisms in antimicrobial resistance of Cutibacterium acnes

  • Hai Tang Tuan, Thu Pham Hien Anh, Van Pham Thi Thanh, Vinh Ngo Minh, Chuong Nguyen Hoang
Từ khóa: Cutibacterium acnes, antimicrobial resistance, 23S rRNA, 16S rRNA..

Tóm tắt

   Cutibacterium acnes is a Gram-positive, facultative anaerobe that forms the human skin’s commensal flora. The microbe plays an important role in the pathogenesis of acne vulgaris, as in endocarditis and prosthetic joint infectious arthritis. In Europe, the resistance rates of C. acnes to Clindamycin and macrolides were reported to be relatively high, while in Vietnam, raw data noted the increasing rate of resistance to broad-spectrum antibiotics indicated for acne treatment following the Ministry guideline.

Regarding molecular mechanism, macrolide resistance is associated with point mutations at 23S rRNA and 16S rRNA encoding genes, leading to the alteration in ribosome structure and, thus, inhibition of the bacterium’s protein synthesis. Performing routine evaluation of antimicrobial resistance (AMR) and associated mutations is essential. Therefore, this review aims to explore the status and mechanism of AMR to available antibiotics.

DOI: 10.59715/pntjmp.4.2.2

điểm /   đánh giá
Phát hành ngày
2025-04-20
In ra
Tập. 4 Số. 2 (2025)
Chuyên mục
Tổng quan (Review)