Genotype characteristic of MTHFR C677T, MTHFR A1298C, MTR A2756G, MTRR A66G polymorphisms in recurrent pregnancy loss

Abstract

This research aimed to investigate the correlation between genotype of single nucleotide polymorphisms MTHFR C677T, MTHFR A1298C, MTR A2756G, MTRR A66G and recurrent pregnancy loss (RPL). A case-control study was performed on 92 women suffering from URPL and 92 women who had a normal history of pregnancy. Regarding MTHFR C677T, the average numbers of alleles, heterozygous genotypes, and mutant homozygous genotypes were significantly higher in the group with RPL (p<0.05), women with these genotypes had a greater incidence of having recurrent pregnancy losses 2.5 fold (OR 2.5, 95% CI, 1.27-4.94, p=0.0041), and 4.57 fold (OR 4.57, 95% CI, 1.05-27.41, p=0.0190), separately. Otherwise, the cases were also significantly higher in MTR A2756G mutant allele versus the controls (p<0.05). However, in terms of the MTHFR A1298C, MTR A2756G, MTRR A66G polymorphisms, the obtained results were similar and they were not risks factor of recurrent pregnancy loss (p>0.05). The polymorphism MTHFR C677T is a risk factor for the RPL in the participants. Regarding the MTHFR A1298C, MTR A2756G, and MTRR A66G polymorphisms, more research has to be done to further analyse their correlation.