Effects of some carbon and nitrogen sources on antibacterial activity of sponge-derived Streptomyces sp. strain HM9

Abstract

Streptomyces has been known as a source of natural bioactive substances so far. In this present study, the sponge-derived Streptomyces HM9 was optimised with a number of different carbon (C) and nitrogen (N) sources to evaluate the broad-spectrum antibacterial ability. Starch and (NH₄)₂SO₄ were favourable carbon and nitrogen sources to the growth of the strain HM9. Starch and casein were suitable carbon and nitrogen sources for antibacterial activity of strain HM9 against Vibrio, whereas lactose and NH₄Cl were beneficial on the inhibition of standard indicator Bacillus subtilis ATCC 6633