Association between RAD51 gene polymorphism rs1801321 and ovarian cancer risk.

Abstract

Ovarian cancer is one of the most common gynecological malignancies. The gene RAD51 involves homologous recombinational repair for double-strand breaks of DNA, so its polymorphisms and mutations are associated with cancer risk. The authors studied, by using a case-control design, whether single nucleotide polymorphism rs1801321 of RAD51 gene associated with ovarian cancer risk among Vietnamese females. Sample sets included 380 ovarian cancer cases and 380 healthy controls of similar age distribution. The genotypes of rs1801321 polymorphism were determined using the Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The distribution of genotype GG, GT, TT was 55.3, 29.2, 15.5% for the patients group and 47.9, 41.8, 10.3% for the control group, respectively (p=0.001). The RAD51 rs1801321 polymorphism was associated with the risk of ovarian cancer among Vietnamese females.