A study on preparation of 18F-Choline radiopharmaceutical at 108 Military Central Hospital.

Abstract

¹⁸F-Choline (¹⁸F-FCH) radiopharmaceutical is used in PET, PET/CT scans to diagnose prostate cancer (PC) and hepatocellular carcinoma (HCC). Currently, this radiopharmaceutical is not available in Vietnam. Because the physical half-life of Flo-18 is only 110 minutes then 18F-FCH radiopharmaceutical cannot be imported from abroad. Therefore, the only option to have this radiopharmaceutical for clinical research and diagnosis is domestically produced. The purpose of the research is to prepare ¹⁸F-FCH to meet the 2017 European Pharmacopoeia standards (EuPh2017). The method of preparing 18F-FCH is carried out on an automatically controlled radiochemical synthesis module. The experimental results confirm that the total time of the synthesis of an ¹⁸F-FCH batch is 40±2 min. Synthesis yield is 15±5% after decay correction. Radiochemical purity is more than 99.9% that meets the requirements of EuPh2017 for PET radiopharmaceutical.