STUDY ON FACTORS INFLUENCING SYNTHESIS OF ETHYL 3-AMINOCROTONATE

Tóm tắt

β-amino crotonate are compounds of interest since they find use as
intermediates for the synthesis of Ca channel blockers such as Nisoladipine,
Benidipine, Nicardipine and Felodipine. The method is characterized by allowing
reaction between ethyl acetoacetate and ammonium acetate in methanol
solution at a room temperature, for 20 hours and molar ratio ethyl acetoacetate
with ammonium acetate is 1:3. The structure of the obtained product were
determined by IR, 1H-NMR and LC- MS spectroscopic data.