SYNTHESIS AND CHARACTERIZATION OF POLY(VINYL PHOTPHONIC ACID)-CHITOSAN USING TETRAETHYLENE GLYCOLDIMETHACRYLATE CROSSLINKER

Abstract

In this study, poly(vinylphosphonic acid)-chitosan (PVPACS) hydrogel was prepared via
in situ polymerization of vinyl phosphonic acid (VPA) and chitosan (CS) in the presence of
tetraethylene glycoldimethacrylate (TEGMA) crosslinking agent agent with amoni pesunphat
APS as initiators. Characteristics of hydrogel were determined by the swelling, gelation time,
fourier transform infrared spectrum (FTIR), thermogravimetric analysis (TGA) and calcium
chelation test. The results showed that the swelling and gelation time behavior increased with
the increase of VPA contents. FTIR spectroscopy clearly indicated the proton exchange
reactions between VPA and CS forming ionic crosslinks. PVPACS has an ability to chelate form
between acid groups with Ca2+ ions from the surrounding environment ion. At 30% VPA
contents, the maximum adsorption capacity of Ca2+ was 90.5mg/g at pH = 7 and 125.7mg/g
at pH = 10, respectively. Calcium chelation test showed potential for bone tissue engineering
applications.