Determination of acute toxicity and anti – inflammatory activity of Gomphrena celosioides Amaranthaceae extract
LÊ THỊ KIM ANH
TRẦN NGỌC TÍN
TRƯƠNG MỸ LINH
NGUYỄN THỊ TRÚC LINH
NGUYỄN HOÀNG MỸ AN
HOÀNG THỊ PHƯƠNG LIÊN
VÕ THỊ THU HÀ
Abstract
Introduction: In Viet Nam, the study of No ngay dat (Gomphrena celosioides Mart.) is still limited. Therefore, this study was conducted for the purpose of determining acute toxicity and evaluating the anti - inflammatory effects of Gomphrena celosioides aqueous extract.Materials and Methods: To determine acute toxicity, the study enrolled mice for oral dosing at the maximum possible oral dose and recorded live or death of mice in the next 72 hours. A carrageenan - induced paw edema assay was performed to evaluate the anti-inflammatory effects of Gomphrena celosioides. After inflammation, the mice were given a therapeutic dose and monitored the paw volume every day during the test.Results and Discussion: The results showed that aqueous extract at 11,8g/kg (Dmax) did not kill the test mice and not have acute oral toxicity. Besides that, aqueous extract also has anti-inflammatory effect at 300mg/kg and 600mg/kg.Conclusion: Gomphrena celosioides is not toxic at the tested dose and shows significant anti - inflammatory activity. This is a highly potential medicinal plant for the treatment of inflammatory diseases and should be isolated some bioactivity compounds or investigates the others pharmacological effects.