Phytochemical screening and biological activities of Gnetum montanum Markgr. extracts

Abstract

   Background: Studying the chemical compositions and biological effects of medicinal herbs are the current focuses in our country. Objectives: To analyse the phytochemical compositions, examine biological activities of Gnetum montanum extracts. Methods: Gnetum montanum powder was examined for the phytochemical compositions and major compound groups were assessed based on the method of Ciuley with modifications. The total alkaloids content was determined using Namba method. The total flavonoid and saponin contents were determined using weighing method. Antibacterial, antioxidant and α-amylase and α-glucosidase inhibitory activities were addressed by agar diffusion, DPPH free radical scavenging assay, and spectrophotometrical methods. Results: The results showed that Gnetum montanum contain the major constituents of oils, fats, anthraquinones, antraglycosides, flavonoids, alkaloids, tannins, triterpenoids, saponins, reducing agents and organic acids. The contents of alkaloids, flavonoids and saponins were 3,29%, 1,94% và 2,13% of the raw materials, respectively. Gnetum montanum extracts presented antibacterial, DPPH free radical scavenging, and in vitro α-amylase and α-glucosidase inhibitory activities. Conclusion: Gnetum montanum could be suggested as a potential natural source of antibiotics, antioxidant and antidiabetic compounds that can be used for the prevention or treatment of diseases.