TREATMENT RESULTS IN RECURRENT BREAST CANCER PATIENTS AT THAI NGUYEN NATIONAL HOSPITAL

Abstract

The treatment of cancer recurrence in general as well as breast cancer still faces a number of obstacles due to many problems such as drug resistance, disease characteristics, and toxicity encountered at the initial treatment stage. The study aims to evaluate the results of treatment and some related factors in recurrent breast cancer patients. The study was conducted on 40 patients with recurrent breast cancer treated at Oncology Center of Thai Nguyen National Hospital from 01/01/2019 to 31/12/2021. Patients are mainly treated with chemotherapy. In the chemotherapy group, the rate of response was 28.6%. Patients with invasive carcinoma of no special type, hormone receptor positive, Her-2/neu (-) or 1+ positive had a higher response rate than the group of patients with other histologic types, hormone receptor negative and Her2/neu 3+ (31.0% vs 16.7%; 38.9% vs 21.4%; 53.8% vs 15.8%); however, the difference was not statistically significant (p>0.05). The most common chemotherapy toxicity was grade 1.2. There was no relationship between histologic type, hormone receptor, Her-2/neu expresion, hostologic grade and visceral metastasis status with treatment response rate. Treatment regimens was low toxicity and consistent with the tolerability of the majority of patients.