DRUG CARRIER POTENTIAL AND CHARACTERIZATION OF NANO-CELLULOSE 3D-NETWORKS PRODUCED BY ACETOBACTER XYLINUM OF FERMENTED AQUEOUS GREEN TEA EXTRACT
Abstract
Nano-cellulose 3D-networks (NA3D) could be produced by Acetobacter xylinum (A. xylinum) living in the fermented aqueous green tea extract. NA3Ds include nano fibers forming networks, which are capable of drug loading to form a prolonged release therapy to improve drug bioavailability. Ranitidine is a gastrointestinal H2 receptor antagonist drug with low bioavailability (50%). In this study, NA3Ds are biosynthesized by A. xylinum in the standard medium (SM), coconut water (CW) and rice water (RW). The NA3Ds obtained from CW, and RW have the same characteristics as the NA3D obtained from the SM, and NA3Ds can be fabricated with the desired thickness and diameter in all three types of culture media. NA3Ds absorbed ranitidine in optimum condition did not differ statistically significantly (p > 0.05) in both ranitidine loading (111.6-116.7 mg) and ranitidine entrapment efficiency (61-63%). The NA3Ds were characterized by using field emission scanning electron microscopes (FE-SEM) and fourier transform infrared (FTIR) spectroscopy. Investigation of the NA3D structure using SEM showed that the cellulose fibers of NA3D-SM and NA3D-CW have a stable structure without structural change when loading drug. The results indicate the potential for using NA3D-SM and NA3D-CW to fabricate the drug delivery system.