STUDY ON THE IN VIVO BIOAVAILABILITY OF 3DNC-SM-CUR FOR ORAL OR TRANSDERMAL ADMINISTRATION

Abstract

Curcumin (CUR) has many biological effects and safety for human but has low bioavailability. 3D-nano-cellulose (3DNC) networks were produced by Acetobacter xylinum in standard medium (SM) used as CUR carrying material, 3DNC-SM-CUR has been proven to prolonged release curcumin in vitro. The purpose of this study was to evaluate the in vivo bioavailability of 3DNC-SM-CUR for oral or transdermal administration. The concentration of CUR in rabbit plasma after use of 3DNC-SM-CUR was quantitatively analyzed by using ultra performance liquid chromatography (UPLC). The pharmacokinetic parameters such as maximum CUR concentration (C_max), maximum CUR concentration time (T_max), area under curve (AUC), CUR half-life (t_1/2), and so on were calculated using the compartmental method with PKSolver program. The results of oral or transdermal administration of 3DNC-SM-CUR in rabbits showed that 3DNC-SM-CUR can create a prolonged CUR release system. The in vivo bioavailability of 3DNC-SM-CUR administered orally was 342%, while 3DNC-SM-CUR was administered in the transdermal patch at the same CUR concentration with an in vivo bioavailability of 368%. 3DNC-SM-CUR has increased CUR bioavailability compared to pure CUR in both oral and transdermal administration in rabbits.