EFFICACY OF A DCBRN-01VN SKIN DECONTAMINANT ON ANIMALS EXPOSED TO 2-CHLOROETHYL ETHYL SULFIDE

  • Ngoc Doan Vu Faculty of Physics and Chemical Engineering, Le Quy Don Technical University, Hanoi, Vietnam
  • Quang Hung Vu Institute of Chemistry and Material, Academy of Military Science and Technology
  • Thanh Vinh Nguyen Faculty of Physics and Chemical Engineering, Le Quy Don Technical University, Hanoi, Vietnam
  • Ba Cuong Nguyen Faculty of Physics and Chemical Engineering, Le Quy Don Technical University, Hanoi, Vietnam
Keywords: Decontamination, DCBRN-01VN, sulfur mustard, CEES

Abstract

Chemical warfare agents are an actual threat and decontamination for victims is a main concern when mass exposure occurs. The study evaluated the effectiveness of the skin decontamination agent DCBRN-01VN based on the oxime compound KBDO for CEES (2-chloroethyl ethyl sulfide). HPLC analysis method was used to determine the temperature after decontamination in vitro and in vivo tests and then to check biochemical and hematological indicators in rats. The test results show that DCBRN-01VN has a high efficiency of CEES decontamination, in vitro: with the ratio of CEES: decontaminant 1:20 in 10 minutes reaching 55.04%, with the ratio 1:10 in 20 minutes reached 55.95%, in 30 minutes reached 82.93%, in 60 minutes reached nearly 100%; in vivo test with a ratio of 1:15 in
20 minutes reached almost 100%. Results of biochemical and hematological examination showed no difference between the negative control group and two experimental groups (with decontamination and without decontamination) P(2-1) > 0.05; P(3-1) > 0.05. Histopathological analysis showed that decontamination also reduced damage caused by CEES.

điểm /   đánh giá
Published
2023-11-24
Issue
Vol. 1 No. 02 (2023)
Section
SCIENTIFIC RESEARCH