C-H BOND HALOGENATION OF BENZOXAZINONES BY PALLADIUM CATALYSTS

  • Huu Manh Vu Faculty of Physics and Chemical Engineering, Le Quy Don Technical University, Hanoi, Vietnam
  • Ngoc Doan Vu Faculty of Physics and Chemical Engineering, Le Quy Don Technical University, Hanoi, Vietnam
  • Trung Hieu Le Institute of Chemistry and Materials, Academy of Military Science and Technology, Hanoi, Vietnam
  • Xuqin Li School of Chemical and Biological Engineering, University of Science and Technology Beijing, Beijing, PR China
Keywords: Palladium catalyst, benzoxazinone, C-H activation, halogenation

Abstract

In this research, palladium-catalyzed C-H bond halogenation of benzoxazinone derivatives has been achieved. This approach shows high regioselectivity and wide substrate scope, the products are obtained in moderate to good yields. The plausible mechanism was discussed, the reaction may have gone through a PdII/PdIV/PdII process. This protocol provides a simple and effective synthesis pathway for various halogenated benzoxazinone derivatives.

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Published
2023-11-24
Issue
Vol. 1 No. 02 (2023)
Section
SCIENTIFIC RESEARCH