Genetic characterizations of genome of chicken infectious anemia viruses (CIAV) in the North, Viet Nam

Abstract

The genome of chicken infectious anemia virus (CIAV) contains non-protein coding and protein coding regions. Up to date, there is no available study on the genome characterization of CIAV in Viet Nam. This study aimed at genetic characterization of the field CIAV strains belonging to genogroup II and genogroup III detected in the North, Viet Nam. The studied result
revealed that all of three field strains exhibited typical genetic structure of CIAV, including the 5’ promoter region which was followed by partial overlapping, unisense open reading frames in the order of ORF2- ORF3- ORF1. Three field CIAV strains in this study displayed typical genetic variations of CIAV in the worldwide. Of which, the gene encoding capsid protein was the most variable compared to the others two genes. The signature motif of either
75V97M139K144E or 75I97L139Q144Q was detected in these field strains. Noteworthy, the sequence pattern of attenuation or lower pathogenicity (75I- 89T- 125L- 141L- 144E) was not observed in the three field strains.