Using the Gulnea plg in potency test for the foot and mouth disease vaccines

Abstract

The objective of this study aimed at evaluating the use of Guinea pig to test the efficacy of Foot and Mouth Disease (FMD) vaccines by means of determining 50% protection dose  (GPPD50). The  FMD  vaccines  used  in this study were  Aftopor type “O”, imported vaccine from MeÙrial  company; Aftovax type “O” and type “O”+”A” formulated at NAVETCO using the antigens of the inactivated FMD virus from MeÙrial company; and the FMD vaccine made by NAVETCO using the FMD virus isolated in Viet Nam. A total of 16 vaccine lots were tested and the results indicated that all of the 16 vaccine lots reached the potency standards with the GPPD50 value was ≥ 23 GPPD50/dose. It was also recognized that all the vaccine lots showed their efficacy in the test on the Guinea pigs with the value ≥ 23 GPPD50/dose, the same value also obtained when efficacy test was done using the target animals as pig or cattle. With the outcome of this study, it is suggested that the Guinea pigs can be used for potency test for FMD vaccines