FLAVONE GLYCOSIDES CONSTITUENTS FROM THE LEAVES OF FISSISTIGMA TONKINENSIS (FIN. & GAGNEP.) MERR

Abstract

Fissitigma tonkinensis is a small woody species. According to traditional medicine, the root bark
of this species is often used to bundle broken bones. This species is distributed in Quang Ninh, often
growing naturally in the margins of secondary forests [1]. So far, there have been no announcements
on the chemical composition and biological activity of this species. In this paper, phytochemical
constituents of the methanol extract of the leaves of the F. tonkinensis were studied. Six flavone
glycoside compounds were isolated by the combination of various chromatographic methods. The
chemical structures of these compounds were identified to be kaempferol 3-O-α-L-rhamnopyranosyl
(1→6)-β-D-galactopyranoside (1), kaempferol 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-
galactopyranoside (2), rhamnetin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (3),
isoquercitrin (4), kaempferol 3-O-β-D-glucopyranoside (5), quercetin (6) by analyzing one
dimensional (1D) and two dimensional (2D) nuclear magnetic resonance spectroscopy (NMR) in
comparison with the corresponding data reported in the previous literature.