STUDY ON PROCESS FOR PRODUCTION OF HARD CAPSULE USING TO SUPPORT TREATMENT CARDIOVASCULAR DISEASES USING Cratoxylum formosum Dyer., Gardenia Jasminoides Ellis., Lycopodium cernuum L.

Abstract

The compound CFE1 (Hyperoside) was isolated from EtOAc extract of
Cratoxylum formosum Dyer., together with studies proving the presence of
genipin, geniposide, crocetin in Gardenia Jasminoides Ellis. and huperzin A in
Lycopodium cernuum L. These compounds have valuable biological activities such
as anti-inflammatory, antioxidant, blood activator, treatment of atherosclerosis,
and other cardiovascular diseases. Therefore, hard capsules have been prepared
from 3 materials, helping to support the treatment of cardiovascular diseases. In
addition, hard capsules have been successfully prepared from 3 materials with
physico-chemical criteria such as the uniformity of the capsule's mass,
disintegration, content of moisture, ash. The standards of capsule preparation
followed the regulations of the Ministry of Health and Vietnamese
Pharmacopoeia IV. Thereby, it has opened up new directions of research to use 3
these materials in supplements and drugs to support the treatment of other
cardiovascular diseases.