CYTOTOXIC ACTIVITY OF NEW PHENOLICS FROM DIANELLA ENSIFOLIA (L.) DC.

Abstract

In our previous study, 10 compounds were isolated and structurally
identified from the aerial part of Dianella ensifolia. Three of them (1, 2, and 4)
were newly identified compounds and one (3) was obtained for the first time as
natural product.With the aim to search for the cytotoxic agents from this plant,
the present investigation was designed to evaluated cytotoxic activity of a
phenolics (1-4) against four human cancer cell lines Hep3B, Hela, A549, and
MCF-7. Of them, compound 4 (at 100μM) showed the most effects on A549 and
MCF-7 cells, with the survival rates of 42.07% and 49.49%, respectively, while
the positive control camptothecin (5μg/ml) resulting in the rates of 26.75% and
28.89%, respectively.