FLAVONOIDS AND THEIR CYTOTOXIC ACTIVITY FROM TITHONIA DIVERSIFOLIA

Abstract

Three flavones (1-3) were isolated from the aerial part of Tithonia
diversifolia (Hemsl.) A. Gray growing in Hoa Binh province, Vietnam. Their
structures were identified as hispidulin (1), nepetin (2) and luteotin (3) by
analysis of these spectroscopic MS, NMR data and comparison with reported
data. The compounds 1-3 showed cytotoxic activity against four human cancer
(KB, Hep, Lu1 and MCF7) cell lines with IC50 values ranging from 16.13 ±
0.89g/mL to 99.63±1.02g/mL. Among them, compound 3 has shown the
most potent effect on Hep and KB cell lines with IC50 16.13 ± 0.89g/mL and
24.45 ± 0.97g/mL, respectively.