STUDY ON CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITY OF HETEROSTEMMA GRANDIFLORUM COST.

Abstract

Heterostemma grandiflorum Cost. is a flowing plant of Asclepiadaceae
family, distributed in Hoa Binh, Ha Noi, Ha Nam,... provinces. Our literature
searchs showed that this species was not chemically as well as biologically
studied until now. This is the first report about phytochemistry and cytotoxicity
results of H. grandiflorum collected in Me Linh, Ha Noi. From dichloromethane,
butanol extracts of H. grandiflorum’s twigs and leaves 4 compounds have been
isolated. Their structures were elucidated by the 1D and 2D NMR spectroscopy
and comparison with published data. They include α-amyrin acetate,
neoilexonol acetate, apigenin-7-O--D-glycoside and-sitosterol glucoside.