STUDY ON THE STRUCTRAL AND BIOLOGICAL ACTIVITY OF COMPLEXES Zn(II) WITH 2 - ACETYLPYRIDINE THIOSEMICARBAZONE

Abstract

   The ligand 2 - acetylpyridine thiosemicarbazone (Hthacpyr) was synthesised from thereaction of 2 - acetylpyridine and thiosemicarbazide. It reacts with zinc nitrates, in theabsence of ammonia to form Zn(thacpyr)2. Structure and spectroscopic of ligand andits complex has been studied. The result of methods: IR, 1H -NMR, 13C -NMR, MS andX -ray diffraction show that in the complex, ligand was deprotonated and behaved astridentate ligand, bonding to Zn(II) via N(1), Npyridineand S donor atoms. Theantimicrobial, antifungal of the ligand and its complex has also been investigated. Thebiological activity of the complexe was higher than that of the free ligand.

Keywords: Ligand, 2 - acetylpyridine thiosemicarbazone, complexe, ligand,antimicrobial and antifungal.