STUDY ON -GLUCOSIDASE INHIBITORY ACTIVITY OF MEDICINAL PLANTS FROM DONG THAP

Abstract

    Study on -glucosidase inhibitory activity of 20 methanolic extracts of medicinal plants fromDong Thap. The results showed that 17 extracts displayed activity at 250 μg mL-1, 16 extractsshowed an inhibition rate greater than 50 % at 250 μg mL-1, 9 extracts had over 50 % at 100μg mL-1, 7 extracts possessed more than 50 % at 50 μg mL-1, 5 extracts showed over 50 % at25 μg mL-1 and 2 extracts had greater than 50 % at 10 μg mL-1. Among them, the MeOHextracts from the stems of Ceiba pentandra and the stems of Morus alba exhibited the moststrong -glucosidase inhibitory activity, with IC50 values of 4.8 and 6.1 μg mL-1, respectively,which were stronger than a positive control acarbose with an IC50 values of 138.4 μg mL-1.

Keywords: Dong Thap, medicinal plants, α-glucosidase, Ceiba pentandra, Morus alba.