ASSESSMENT OF THE POTENTIAL FOR BLOOD GLUCOSE CONTROL WITH ALOE VERA GEL

Abstract

  N-hexane extract (EH) of Aloe vera gel was evaluated by the potential for blood glucose controlusing in vitro inhibitory assays and diabetic type II animal model. The α-amylase inhibitory of EHof aloe vera gel were assessed at dose of 50 - 275 μg/ml of EH with percentage inhibition rangingbetween 21,01 - 33,44%. Their corresponding 50% inhibition concentrations were found to be447,33 μg/ml. The antidiabetic effect of EH in normal and alloxan monohydrate (120 mg/kg bodyweight) induced diabetics mice. Group 1 and 2 mice were normal and given orally 8 mgEH/day,diabetes was induced in group 3 and 4 mice, treated/or not with EH. The fasting blood glucoselevel was determined at different time in 22 days treatment. There were no diffirence of bloodglucose levels in group 1, but decreased 6% in group 2 and the body weight in both groupincreased 1,8g in 22 days. Average increase in fasting blood glucose levels and body weight wasobserved in groups 3 mice which are diabetic control group, died seven days later but asignificant decrease 39% and 8,16%, respectively, was in group 4.These findings suggest that Aloevera gel have a blood glucose level control effect and would be candidate in functional food forthe treatment of type 2 diabetes mellitus.

Keyword(s): Aloe vera gel, type 2 diabetes.,