OCCURENCE OF 20 PHARMACEUTICAL RESIDUES IN SURFACE WATER OF SEINE RIVER (FRANCE)

Abstract

    Pharmaceutically active compounds in the environment recently have known as the agent toconstitute a health risk for aquatic ecosystems. The occurrence of pharmaceutical residues inthe wastewater seems to be affected by their production and their consumption. A screening of20 used pharmaceuticals was investigated in surface water of Seine River in France fromMars 2011 to November 2011. 5 sampling points where has taken 8 samples for each pointhas been collected from upstream at Poses to dowstream at Honfleur. These compounds weredetected with high frequencies (>90%) for some compounds such as cafeine, carbamazepine,diclofenac, ketoprofene or never found for alprazolam, doxepine and fluoxetine. Theconcentration of each compound has been varied from some ng/L to some hundred ng/L.Moreover, the total accumulation of these compound has been decreased from upstreeam todowstream, especially in water front where are totally sea water.

Key words: pharmaceutical residues, LC-MS/MS, surface water, Seine River