COMPLEXES OF Cu(II) WITH THIOSEMICARBAZONE BENZALDEHYDE AND THIOSEMICARBAZONE ISATIN

Abstract

      Complexes of benzaldehyde thiosemicarbazone (HL1), benzaldehyde N(4)- phenyl thiosemicarbazone (HL2), isatin thiosemicarbazone (HL3) and isatin N(4)- methyl thiosemicarbazone (HL4) with copper(II) were synthesized in base medium of NH3. Form of these complexes were Cu(L)2, which L: L1, L2, L3, L4. The chemical structures of ligands and their complexes were characterized by elemental analysis, MS, IR, 1H- NMR and 13C- NMR spectroscopy. The obtained results showed that the ligands are bidentate, coordinated to the copper(II) over N, S- donor atoms. The test in vitro antibacterial activities of the ligands and their complexes against three of positive bacteria types: Lactobacillus fermentum, Bacillus subtilis, Staphylococcus aureus and three of negative bacteria types: Salmonella enterica, Escherichia coli, Pseudomonas aeruginosa and one type of fungus: Candida albican show that Cu(L2)2 againt 3/7 bacteria and fungus type.