STUDY OF FACTORS AFFECTING DECOMPOSITION PROCESS ANTIBIOTIC SARAFLOXACIN BY PHOTOCHEMISTRY

Abstract

   Photolysis of Sarafloxacin in water was investigated under irradiation using a Xenon lamp. The results showed that Sarafloxacin photolysis followed apparent first -order kinetics. Compared with the acidic and basic conditions, the photolysis rate was faster at neutral condition. Although the presence of ion perclorate did not influence the drug photodegradation, both of sulfate and cloride can markedly decrease the degradation rate of Sarafloxacin because they can competitively absorb photons with Sarafloxacin. Rapid drug dissipation was observed in the presence of additives hydrogen peroxide. The findings were also substantiated by the quantum yield () calculations. The analytical measurements were carried out with HPLC/PDA.