SYNTHESIS, STUDIES ON THE COMPLEXES OF Zn(II) WITH THIOSEMICARBAZONE BENZALĐEHYDE AND N(4)- PHENYL ITS DERIVATIVE

Abstract

   Thiosemicarbazone benzaldehyde (Hthbz) and N(4) - phenyl thiosemicarbazone benzaldehyde (Hpthbz) react with zinc(II) in solution and present of NH3 to afford the complexes in form [ZnL2] (L is thbz or pthbz). These ligands and their complexes were synthesized characterized by means of elemental analysis, MS, 1H- NMR and 13C - NMR, IR, UV- Vis spectroscopy. The obtained results showed that Hthbz and Hpthbz coordinated to zinc(II) over N, S - donor atoms and two ligands are bidentate. The antibacterial activities of the ligands and their complexes were tested in vitro against three of positive bacteria types: Lactobacillus fermentum, Bacillus subtilis, Staphylococcus aureus and three of negative bacteria types: Salmonella enterica, Escherichia coli, Pseudomonas aeruginosa and one type of fungus, that is Candida albican.  Keywords: thiosemicarbazone; Zn(II) complex; benzaldehyde.