NGHIÊN CỨU CÁC YẾU TỐ ẢNH HƯỞNG ĐẾN QUÁ TRÌNH PHÂN HỦY THUỐC KHÁNG SINH SARAFLOXACIN BẰNG QUANG HÓA UV
Lê Trường Giang
Bùi Thị Ngọc Thơm
Đào Hải Yến
Nguyễn Ngọc Tùng
Tống Thị Thanh Thủy
Cao Văn Hoàng
Tóm tắt
Photolysis of Sarafloxacin in water was investigated under irradiation using a Xenon lamp. The results showed that Sarafloxacin photolysis followed apparent first -order kinetics. Compared with the acidic and basic conditions, the photolysis rate was faster at neutral condition. Although the presence of ion perclorate did not influence the drug photodegradation, both of sulfate and cloride can markedly decrease the degradation rate of Sarafloxacin because they can competitively absorb photons with Sarafloxacin. Rapid drug dissipation was observed in the presence of additives hydrogen peroxide. The findings were also substantiated by the quantum yield () calculations. The analytical measurements were carried out with HPLC/PDA.