Status research Thalassemia carier among children of ethnic Tay, Dao in Tuyen Quang province

Abstract

Objectives: To determine the prevalence of thalassemia carrier, genotype and hematological parameters among children bearing the thalassemia gene in Tuyen Quang. Methodology: A descriptive study was conducted from January to March 2017. 505 ethnic minority children in 6 districts and Tuyen Quang City, Tuyen Quang province were registered voluntarily by the family in the study. MCV index <80fL combined with the DCIP test were used for screening thalassemia and HbE. Hemoglobin electrophoresis and DNA analysis of mutations in the globin alpha gene was performed for all cases positive with screening tests. Results: The prevalence of thalassemia common for ethnic minority children in Tuyen Quang was 28,1%. Four types of single-gene mutations in the alpha globin gene were identified, following types --^SEA, -α^3.7; -α^CS; -α^4.2. Conclusion: The general prevalence of thalassemia gene among the Tay and Dao children in Tuyen Quang is 28.1%. Six phenotypic groups carrying thalassemia gene were detected with 10 mutant genotypes. Mutation - SEA accounts for the highest proportion of single allele mutations (72.09%).