THBS1 is potential target of mir-144-3p in osteoarthritis

Abstract

MicroRNA is a small RNA molecule (about 20 - 25 nucleotides) that does not participate in coding, which regulates gene expression by inhibiting transcription or translation. In recent years, osteoarthritis is considered the second leading cause of the increasing number of people living with a disability. With the aging population of the world in general and Vietnam in particular, osteoarthritis is a big challenge in diagnosis and treatment at an early stage. MiR-144-3p is one of the molecules that have been shown to function in osteoarthritis. However, the network of microRNAs interacting with the target gene system in a disease condition is extremely complex. In order for the function of the miR-144-3p molecule to be complete, it is necessary to step by step determine the function in disintegrating joint disease conditions for certain potential target genes. The target gene of miR-144-3p was predicted using tools such as Target Scan Human, miRDB, and miRmap. Predictive results showed that THBS1 was identified as the target gene of miR-144-3p with 04 coupling sites and functionally related to dead joint disease through the TGF-β signaling pathway.