ABCA1 is a potential target of miRNA-144 in chondrocyte

Abstract

MiR-144-3p is known to play a key role in cartilage biology, with potential effects in osteoarthritis (OA). An insight into the function of miRNAs of practical importance for future miRNA-based therapy. However, the biological role of this miRNA has not been clearly defined. The physiological function of an individual miRNA will be determined through its mRNA targets, and ABCA1 is reported to be involved in chondrocyte differentiation, maturation, and phenotype maintenance, this study proves that ABCA1 is a direct target of miR-144-3p. The bioinformatics tool was performed to predict potential signaling pathways that interact with miR-144-3p in chondrocyte cells. The binding sites of miR-144-3p in ABCA1 3’UTR were identified. These data suggest that ABCA1 could be a potential target for miR-144-3p in chondrocyte cells.