Synthesis of the reversed stationary phase for solid phase extraction using trimethoxyoctadecyl silane

Abstract

Octadecyl grafting silica was synthesized using trimethoxyoctadecyl silane. Reaction conditions were optimized so that the carbon percentage of resulted material was similar to that of commercial products. Temperature and catalyst played very important roles in the reaction. The material was also undergone the end-capping process to reduce unreacted silanol groups. Final product owned 14.1 % of carbon content and 75 % of the unreacted silanols. Retention behavior of product was tested and compared to the same noes available on the market. Results showed that both resulted material and commercial had the same retention properties.