BIOLOGICAL CHARACTERISTICS AND STRATEGIES OF STIMULATING ADENOVIRUS ACTIVITIES TO ONCOLYTIC

Abstract

Currently, scientists are always trying to find new cancer treatments in which, employing cytolytic virus to treat cancer has long been paid attention to and aiming at influencing on the virus’s genome for the improvement of treatment effectiveness. Adenovirus is the type of common choice in the method of cell destruction because it can significantly eliminate local immunosuppression and activate anti-tumor immune responses. The objective of this article is to provide information about operation mechanism and some genetic modification strategies of adenovirus; in order to improve anti-tumor activities. Writers have used ‘cytolytic virus’ to collect and analyze information about genetic transformation strategies on website: www.ncbi.nlm.nih.gov from 2014 until now. Adenovirus can be modified capsid (insert peptides or protein domains into the viral capsid) or remove a gene fragment in the aim of enhancing anti-tumor activities without influencing on normal cells’ operations. Clinically, the application of genetically-modified cytolytic virus promises a bright future for cancer treatment.