IN VITRO ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITIES OF ASARUM CORDIFOLIUM

Abstract

Asarum cordifolium was used to bath medicine for back pain, treat an infected wound, hemorrhoids treatment for traditional medical remedies made by Red Dao people in Lao Cai province. In this study, the anti-inflammatory effect and inhibition of nitric oxide production and antimicrobial activities on 11 strains of bacteria and fungus of the extract of crude ethanol (ACM), ethyl acetate (ACE), and water (ACW) of Asarum cordifolium were tested. The results are shown as follows: The ACM extract showed potent anti-inflammatory activity with IC₅₀ value of 6.21 µg/ml and exhibited the best antimicrobial activity with MIC value of 100 μg/mL (for Phytopthora infestans and Collectotrichum phomoides)). The ACE fraction exhibited anti-inflammatory activity with IC₅₀ value of 16.66 µg/ml and exhibited the best antimicrobial activity on Phytopthora infestans with a MIC value of 150 μg/mL. This result has contributed to guide further studies on the chemical composition and biological activity of the extracts and isolated compounds from Asarum cordifolium.