STUYDING ON ALLELE FREQUENCY ADH1B*2 ENCODING ALCOHOL DEHYDROGENASE 1B AT VIETNAMESE INDIVIDUALS LIVING IN THAI NGUYEN CITY

Abstract

Alcohol dehydrogenase 1B (ADH1B) is an enzyme involved mainly alcohol metabolism in humans, there are 3 allele variants affecting the alcohol metabolism of ADH1B (ADH1B*1, ADH1B*2 and ADH1B*3). In which, ADH1B*2 and ADH1B*3 alleles have higher activity in oxidizing alcohol to toxic acetaldehyde than ADH1B*1. In this study, we determined the ADH1B*2 allele frequency in 49 Vietnamese individuals living in Thai Nguyen city, Thai Nguyen province by identifying and analyzing the ADH1B gene sequence. The results showed that, among 49 individuals, there were 5 individuals with homozygous genotype ADH1B*1/ADH1B*1 (10.2%); 29 individuals have the ADH1B*2/ADH1B*2 homozygous genotype (59.2%) and 15 individuals have the ADH1B*1/ADH1B*2 heterozygous genotype (30.6%). Thus, the allele frequencies ADH1B*1 and ADH1B*2 in the study sample group were 25.5% and 74.5%, respectively. The results of this study showed that the gene variants encoding ADH1B for alcohol metabolism (ADH1B*1 and ADH1B*2) in the research group of Vietnamese people have a big difference compared to the published Vietnamese study.