EFFECTS OF Lasia spinosa STEM EXTRACT ON ENZYME GLUCOSE-6-PHOSPHATASE ACTIVITY IN THE LIVER AND KIDNEYS OF DIABETIC MICE

Abstract

The study was conducted to evaluate the regulatory effects  enzyme glucose-6-phosphatase activity in the liver and kidney of Lasia spinosa stem extract on alloxan monohydrate-induced diabetes in mice. In this investigation, diabetes has been induced by intraperitoneal injection of alloxan monohydrate. Induction of diabetes increased the level of blood glucose  and enzyme glucose-6-phosphatase significantly (p<0.05). Administration of Lasia spinosa at 100, 200 and 400 mg/kg body weight doses to alloxan monohydrate induced diabetic mice resulted in a significant decrease (p<0.05) in blood glucose level of the extract administered groups as compared to the diabetic control group. The Lasia spinosa reduced the enzyme glucose-6-phosphatase activity in the liver, kidney was found to be ameliorated in diabetic mice. Histopathological alternations of the liver, kidney tissues were also found to be restored in Lasia spinosa treated diabetic groups. The results showed that Lasia spinosa stem extract, at specific doses, has an anti-diabetic effect through its regulates enzyme glucose-6-phosphatase activity, protect liver and kidney. Hence, this plant extract may be beneficial in the treatment of diabetes.