COMPARISON OF SURVIVAL TIME BETWEEN SMALL CELL LUNG CANCER PATIENTS WITHOUT AND WITH METASTASIS IN DIFFERENT ORGANS

Abstract

Small cell lung cancer is a dangerous disease threatening human life and health. This study was performed to evaluate the risk factors for distant metastasis and the effect of metastasis in different organs on survival in the patient. Patient data were collected from SEER database between 2010-2016. A retrospective study design was used in this study. 4933 patients were screened for analysis, of which 2316 patients had metastases, accounting for 46.9%. During follow-up, 3990 (80.9%) of patients died, of which 3707 (92.9%) died from lung cancer, only 283 (17.1%) died from diseases or causes. Whether or not the patient had metastasis was closely related to age, sex, stage T-stage, N-stage, surgery of primary site, and radiation therapy (P<0.05). Mean survival time in the non-metastatic group was 13 months, in the groups of patients with metastasis were 9 months (lung), 8 months (bone), 7 months (brain), 7 months (liver), and 6 months (multi-organ). Distal metastasis showed a poor prognosis in patients with small cell lung cancer. The difference in prognosis between groups of patients had statistical significance, the order of their survival times was: no metastasis > lung metastasis > bone metastasis, brain metastasis, liver metastasis > multi-organ metastasis.