ANTIOXIDANT, ANTIHYPERGLYCAEMIC AND ANTIHYPERLIPIDEMIC ACTIVITIES OF DRIED EXTRACT FROM OF GRAPEFRUIT (Citrus grandis (L.) Osbeck) PEEL IN ALLOXAN-INDUCED DIABETIC MICE

Abstract

The present study was aimed to evaluate the in vitro antidiabetic (α-glucosidase inhibition assay) and antioxidant (DPPH scavenging and ferric reducing-antioxidant power) activities of dried extract from pomelo peel. The in vivo antihyperglycaemic and antihyperlipidemic activities of dried extract from pomelo peel were performed in alloxan monohydrate-induced diabetic mice. The dried extract from pomelo peel has the ability to inhibit the enzyme α-glucosidase, and possess the antioxidant activity. Administrations of dried extract from pomelo peel at 100, 200 and 400 mg/kg doses to AM-induced diabetic mice resulted in significant decrease (p<0.05) in blood glucose, triglyceride, total cholesterol, LDL-cholesterol and VLDL-cholesterol levels in the serum of the extract administered groups as compared to diabetic control group. The levels of HDL-cholesterol in the serum along with body mass were found to be ameliorated in diabetic mice treated dried extract from pomelo peel. These results demonstrated the beneficial effect of dried extract from pomelo peel in controlling hyperglycaemia and ameliorating oxidative stress associated complications associated with diabetes.