ANTIOXIDANT AND CYTOTOXIC ACTIVITIES OF MILLETTIA DIELSIANA IN VIETNAM
Abstract
Co mau (Millettia dielsiana) is a traditional Vietnamese medicinal plant and belongs to the Fabaceae family with a bitter taste. According to folk experience, this plant is used to treat back pain, knee pain, anemia, paralysis of the limbs, sedation, arthritis, enhanced secretion clearance, and menstrual irregularity. Ethanol extract (MD) and ethyl acetate fraction (MDE) exhibited the highest antioxidant activity using the DPPH method with SC (%) values of 75.15 ± 0.3 and 79.01 ± 0.8%, respectively, and SC50 values calculated of 27.06 and 25.68 µg/mL, respectively. The remaining fractions (MDH, MDW) of MD extract showed no activity. The MD extract and its fractions exhibited cytotoxic activity against human hepatoma cell line (Hep-G2), cervical cancer cells (HeLa), and breast adenocarcinoma cells (MCF-7) according to the MTT method. MDE fraction showed good cytotoxic activity against Hep-G2 and MCF-7 cells with IC50 values of 18.45 µg/mL and 13.52 µg/mL, respectively. The MD extract has the best ability to inhibit the Hep-G2 cancer cell line with IC50 values of 15.01 µg/mL. In addition, the MD extract and its fractions did not exhibit inhibitory activity against Vero cells.