INVESTIGATION OF SCAR TREATMENT EFFECTIVENESS OF THERMAL-RESPONSIVE GEL CONTAINING CURCUMIN-ENCAPSULATED LIPOSOMES
Abstract
This study aims to evaluate scar treatment effectiveness of thermal-responsive gel containing curcumin-encapsulated liposome (GelTM-Lip-CUR). Firstly, Lip-CUR was prepared using a combined method of lipid-film hydration and sonication. GelTM-Lip-CUR was prepared from F127 and PVA. Scar treatment effectiveness of Lip-CUR and Gel-Lip-CUR was carried out using mice Mus. musculus var. Albino. The results indicated that Lip-CUR was successfully prepared with mean particle size, polydispersity index, zeta potential, encapsulation efficieny, payload of 229.6 nm, 0.245, -26.6 mV, 90.2%, 8.1%, respectively. In addition, the results also showed that Lip-CUR was stable under storage conditions. GelTM-Lip-CUR was liquid at a temperature of lower than 25oC and gelled at body temperature. The in vivo results on mice Mus. musculus var. Albino indicated that, scar treatment efficiency of Lip-CUR was higher than that of native CUR, and achieved the highest efficiency at CUR concentration of 0.01 mg/mL. Moreover, GelTM-Lip-CUR exhibited a significant better scar treatment effect compared to Lip-CUR, with the optimal CUR concentration of 0.05 mg/mL. The results of histological analysis indicated that the tissue structure at the scar area of GelTM-Lip-CUR at a CUR concentration of 0.05 mg/mL was nearly fully recovered to normal. Therefore, GelTM-Lip-CUR has a great potential to be widely applied in scar treatment.