NGHIÊN CỨU QUÁ TRÌNH GIẢI PHÓNG CURCUMIN TỪ NANG MICRO TRONG MÔI TRƯỜNG IN VITRO

Tóm tắt

Pectin is a naturally occurring compound possessing nontoxicity, high stability and low cost which is widely used to manufacture drug carriers in order to improve drug efficacy and reduce drug dosage. Previous study led to a successful production of micro curcumin bead using ionotropic gelation method by complexation of low methoxyl amidated pectin as drug carrier, surfactant Solutol^® HS 15 and divalent cation Ca²⁺. In this study, the in vitro dissolution of curcumin from micro curcumin beads was carried out in order to evaluate these of protective effectiveness in the acid medium (pH = 1.2), as well as these of controlled release in the base medium (pH 7.4). The results showed that the release of curcumin from beads was delayed in the pH = 1.2 medium. In contrary, when the pH changed to 7.4, the highest release of curcumin in S10 and S15 beads was achieved after 100 minutes of dissolution, and the slope of release was started controlling after this point of time. The mechanism of curcumin release from beads in intestinal medium was fitted in Korsmeyer-Peppas model. The diffusion of curcumin was influenced by both Fickian diffusion and polymer swelling.