MR spectroscopy and dynamic contrast enhanced imaging for glioma grading

Abstract

Purpose: To evaluate the diagnostic accuracy of magnetic resonance spectroscopy and dynamic contrast-enhanced (DCE) magnetic resonance perfusion for glioma grading.

Materials and Methods: Fifteen patient confirmed pathological glioma who underwent MR spectroscopy and DCE in 3 Tesla MRI machine. The following parameters were used: Ktrans, Ve, Cho/NAA, Cho/Cre. The diagnostic accuracy for glioma grading was determined by ROC analysis. Results: There were 10 patients in the high-grade group and 5 patients in the low-grade group. Ktrans, Ve, Cho/NAA and Cho/Cre measures differed significantly between high and low-grade tumor. The AUC was 0.956 for Ktrans.

Conclusion: Ktrans, Ve Cho/NAA and Cho/Cre parameters demonstrated to be useful for glioma grading.