Evaluation of preventive efficacy of an attenuated African swine fever virus G-delta-I177L strain lyophilized vaccine on pigs

Abstract

The objective of this study was to evaluate the preventive efficacy against African swine fever virus
(ASFV) of a lyophilized vaccine produced from the attenuated ASF virus G-delta-I177L strain on pigs.
The studied results indicated that the G-delta-I177L strain-derived vaccine produced by NAVETCO met
the requirements of sterility, safety and potency. Under the laboratory conditions, 100% of pigs vaccinated
with different batches of the vaccine were protected from lethal doses of the virulent ASFV strain which
was isolated in Viet Nam. The vaccine also showed safe for pigs in the field conditions and 80 - 100%
of the vaccinated pigs were protected from challenging experiment with virulent strains on the 28th day post-vaccination. From the 21st day post vaccination, the pigs could obtain a solid immune status and
there was no different in the antibody response and protection efficacy between the Yorkshire×Landrace
hybrid pigs and the local pigs that was vaccinated with the same above ASF vaccine.