Assessment of releasing progesterone from progesterone releasing intravaginal device in cow

Abstract

A study on “Progesterone releasing Intravaginal devices for improving reproductive ability of cattle in Viet Nam” was conducted. Assessment of releasing progesterone slowly from this device in 4 selected cows was based on the clinical indexes, ear tag and ovary cutting.The progesterone releasing silicone samples were covered on the T shape frame of CIDR (Controlled Internal Drug Release device). The blood samples were collected from the tail vein at the times (1) 1 day before inserting the device , (2) during the device insertion and (3) 1 day after removing the device. Then, P4 progesterone levels were determined by ELISA method. The analysed results showed that, before inserting the device, the P4 progesterone levels were low (0.19- 0.54 ng/ml). The peak of the P4 progresterone levels were observed on the day 1 (4.82- 8.99 ng/ml) lasting up to the day of stopping experiment. This progesterone level reduced quickly to the initial level after removing the device (0.23- 0.56 ng/ml). It is conclused that the slowly releasing progresterone from the Progesterone Releasing Intravaginal Device can be applied and this issue should be further studied