SYNTHESIS OF CHITOSAN-GRAFT-POLY(ETHYLENE GLYCOL) WITH THE ANTIBACTERIAL PROPERTY

  • Chau Ngoc Mai
  • La Thi Thai Ha
  • Tran Trung Hieu
  • Nguyen Thuy An
Từ khóa: Antibacterial polyme, chitosan graft poly(ethylene glycol), grafting copolymer, nature polymer.

Tóm tắt

Chitosan (CS) is one of the most plenteous polymers in nature and itself has enormous potential due to its inherent antibacterial ability and exceptional properties as a biopolymer. However, its brittleness and low mechanical properties limited its utilization. Herein, poly(ethylene glycol) (PEG) was chosen to graft with CS to compensate for CS drawbacks owing to its high flexibility and safety to humans. This paper aimed at synthesizing CS graft PEG through a two-stage approach with high grafting efficiency and evaluating its antibacterial activity after modification. At first, PEG was conversed to PEG-aldehyde as an intermediate for the grafting copolymerization onto CS. The results showed that the AgNO3 concentration of 0.75 wt % at the temperature of 80 °C was the optimum condition to obtain the highest conversion efficiency of ~ 77%. In the next stage, the grafting copolymerization was conducted by the reaction between –NH2 groups in CS and –CHO groups in PEG– aldehyde. With the –NH2/–CHO molar ratio of 10 and the NaBH4/PEG-aldehyde molar ratio of 7.4, the grafting percentage and efficiency achieved the highest values (90 and 35%, respectively) after a 6-hour reaction. The CS–PEG could reduce the glass transition temperature of CS to – 31 °C, indirectly demonstrating the flexible enhancement of CS molecules while the antibacterial effect of CS–PEG reached 99.8 and 98.3% against E. coli and S. aureus, proving the high potential to be applied in the food industry as an antibacterial coating.

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Phát hành ngày
2022-10-20
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