SYNTHESIS AND CHARACTERIZATION OF pH-SENSITIVE POLYMER VIA CARBOXAMIDE GROUP

Tóm tắt

Nowadays, pH-sensitive polymers are more and more interesting in the field of novel drug delivery systems. The important features of these polymers are the change of their physical or chemical properties response to changes in environmental pH. In this study, a series of pH-sensitive polymers (OSA) were synthesized from Suberic acid and Ethylenediamine. The chemical structure of OSA was determined by 1H NMR and FTIR. Thanking to carboxamide groups in chain of the polymers, OSA are polyanions that can release proton at high pH and accept proton at low pH. The pKa and pH sensitive range of OSA were evaluated by titration method. The result revealed the effect of DMF solvent to the pH sensitive range of OSA. Importantly, OSA-2 possessed a pH range from 7.2 to 6.3 and obtained low polydispersity index (PI), high zeta potential value. It is thus concluded that OSA-2 is promising a component of dual pH/temperature sensitive copolymers applied as an injectable drug carrier.