SYNTHESIS OF HYDROXYPROPYL-BETA-CYCLODEXTRIN/ALGINATE NANOPARTICLE AS A NOVEL DRUG DELIVERY SYSTEM

Abstract

The aim of this work was to study a novel nanoparticle system formed from alginate and hydroxypropyl-β-cyclodextrin by ionotropic gelation method and to evaluate their potential for the association and delivery of drugs. The nanoparticles were prepared by electrostatic interactions between Ca2+/alginategel andhydroxypropyl-β-cyclodextrin. Morphology and structure characterization of nanoparticles was investigated by scanning electron micrographs (SEM), transmission electron microscope (TEM), infrared spectra (IR). The nanoparticle size was about 50 – 80 nm and their structure quite regular and consistent. Atersunate, chosen as a model drug, was incorporated into the nanocarriers with association efficiency of 88 %.
Keywords: Nanoparticle, hydroxypropyl-β-cyclodextrin, alginate, atersunat.