ENTEROMORPHA INTESTINALIS STRUCTURE AND BIOACTIVITY OF SULFATED POLYSACCHARIDE FROM GREEN SEAWEED ENTEROMORPHA INTESTINALIS

  • Quách Thị Minh Thu
  • Hoàng Trúc Tâm
  • Lê Thị Hồng Nhung
  • Đặng Vũ Lương
  • Ngô Văn Quang
  • Hồ Đức Cường
  • Thành Thị Thu Thủy
Keywords: Ulvan, Enteromorpha intestinalis, structure, cytotoxic activity

Abstract

In this paper, structure and cytotoxic activity of ulvan, a sulfated
polysaccharide isolated from green seaweed Enteromorpha intestinalis, were
determined. The results showed that the polysaccharide was composed of
rhamnose, galactose, xylose, manose, glucose (mole ratio of Rha : Xyl : Glc equal
to 1 : 0.04 : 0.03), uronic acid (24.5%) and sulfate content (17.6%), its
molecular weight is 210,000 g/mol. This ulvan mainly consists of disaccharide
A3S type: →4)β-D-Glucuronic acid (1→4)α-L-Rhamnose-3-sulfate(1→,
branchs were rhamnose residues linkaged to the main chain at C-2 position. The
ulvan showed a significant cytotoxic activity against hepatocellular carcinoma
HepG2 (IC50 = 31.81 ± 2.87µg/ml), human breast cancer MCF7 (IC50 = 26.45 ±
1.36µg/ml), and cervical cancer Hela (IC50 = 34.68 ± 3.84 µg/ml).

điểm /   đánh giá
Published
2022-04-01
Section
RESEARCH AND DEVELOPMENT